WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:Apoptosis       ID:04210
C=87; O=5; E=0.18; R=28.17; rawP=1.02e-06; adjP=3.67e-05
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000117461 NA PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 8503 ENSG00000117461
2  ENSG00000183943 NA PRKX protein kinase, X-linked 5613 ENSG00000183943
3  ENSG00000023445 NA BIRC3 baculoviral IAP repeat containing 3 330 ENSG00000023445
4  ENSG00000100906 NA NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 4792 ENSG00000100906
5  ENSG00000090376 NA IRAK3 interleukin-1 receptor-associated kinase 3 11213 ENSG00000090376


Database:KEGG pathway       Name:Toxoplasmosis       ID:05145
C=132; O=4; E=0.27; R=14.85; rawP=0.0002; adjP=0.0024
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000117461 NA PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 8503 ENSG00000117461
2  ENSG00000027697 NA IFNGR1 interferon gamma receptor 1 3459 ENSG00000027697
3  ENSG00000023445 NA BIRC3 baculoviral IAP repeat containing 3 330 ENSG00000023445
4  ENSG00000100906 NA NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 4792 ENSG00000100906


Database:KEGG pathway       Name:NOD-like receptor signaling pathway       ID:04621
C=58; O=3; E=0.12; R=25.35; rawP=0.0002; adjP=0.0024
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000106100 NA NOD1 nucleotide-binding oligomerization domain containing 1 10392 ENSG00000106100
2  ENSG00000023445 NA BIRC3 baculoviral IAP repeat containing 3 330 ENSG00000023445
3  ENSG00000100906 NA NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 4792 ENSG00000100906


Database:KEGG pathway       Name:Shigellosis       ID:05131
C=61; O=3; E=0.12; R=24.10; rawP=0.0003; adjP=0.0027
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000106100 NA NOD1 nucleotide-binding oligomerization domain containing 1 10392 ENSG00000106100
2  ENSG00000155849 NA ELMO1 engulfment and cell motility 1 9844 ENSG00000155849
3  ENSG00000100906 NA NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 4792 ENSG00000100906


Database:KEGG pathway       Name:Epithelial cell signaling in Helicobacter pylori infection       ID:05120
C=68; O=3; E=0.14; R=21.62; rawP=0.0004; adjP=0.0029
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000106100 NA NOD1 nucleotide-binding oligomerization domain containing 1 10392 ENSG00000106100
2  ENSG00000143882 NA ATP6V1C2 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2 245973 ENSG00000143882
3  ENSG00000100906 NA NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 4792 ENSG00000100906


Database:KEGG pathway       Name:Chemokine signaling pathway       ID:04062
C=189; O=4; E=0.39; R=10.37; rawP=0.0006; adjP=0.0036
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000117461 NA PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 8503 ENSG00000117461
2  ENSG00000183943 NA PRKX protein kinase, X-linked 5613 ENSG00000183943
3  ENSG00000155849 NA ELMO1 engulfment and cell motility 1 9844 ENSG00000155849
4  ENSG00000100906 NA NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 4792 ENSG00000100906


Database:KEGG pathway       Name:Small cell lung cancer       ID:05222
C=85; O=3; E=0.17; R=17.30; rawP=0.0007; adjP=0.0036
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000117461 NA PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 8503 ENSG00000117461
2  ENSG00000023445 NA BIRC3 baculoviral IAP repeat containing 3 330 ENSG00000023445
3  ENSG00000100906 NA NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 4792 ENSG00000100906


Database:KEGG pathway       Name:Circadian rhythm - mammal       ID:04710
C=22; O=2; E=0.04; R=44.55; rawP=0.0009; adjP=0.0040
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000123095 NA BHLHE41 basic helix-loop-helix family, member e41 79365 ENSG00000123095
2  ENSG00000179094 NA PER1 period homolog 1 (Drosophila) 5187 ENSG00000179094


Database:KEGG pathway       Name:Chagas disease (American trypanosomiasis)       ID:05142
C=104; O=3; E=0.21; R=14.14; rawP=0.0013; adjP=0.0052
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000117461 NA PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 8503 ENSG00000117461
2  ENSG00000027697 NA IFNGR1 interferon gamma receptor 1 3459 ENSG00000027697
3  ENSG00000100906 NA NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 4792 ENSG00000100906


Database:KEGG pathway       Name:Neurotrophin signaling pathway       ID:04722
C=127; O=3; E=0.26; R=11.58; rawP=0.0023; adjP=0.0069
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000117461 NA PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 8503 ENSG00000117461
2  ENSG00000100906 NA NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 4792 ENSG00000100906
3  ENSG00000090376 NA IRAK3 interleukin-1 receptor-associated kinase 3 11213 ENSG00000090376




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).